Jennifer A Nichols

Jennifer A Nichols,

Assistant Professor

Department: EG-BIOMEDICAL ENGINEERING
Business Phone: (352) 294-8803
Business Email: jnichols@bme.ufl.edu

About Jennifer A Nichols

Dr. Nichols is an Assistant Professor in the J. Crayton Pruitt Family Department of Biomedical Engineering at the University of Florida with Affiliate Faculty Appointments in the Department of Mechanical & Aerospace Engineering, the Department of Orthopaedic Surgery & Sports Medicine, and the Department of Physical Medicine & Rehabilitation. She received a B.S. in Mechanical Engineering from Tufts University in 2008 and completed graduate training at Northwestern University, where she received an M.S. in Biomedical Engineering in 2011, an M.A. in Medical Humanities & Bioethics in 2014, and a Ph.D. in Biomedical Engineering in 2014. From 2014 to 2017, she completed a postdoctoral fellowship in the Department of Orthopaedics at the University of Utah. At the University of Florida, she directs the Musculoskeletal Biomechanics Lab. Her research interests include biomechanics, musculoskeletal modeling, complex joint systems such as the foot/ankle and wrist/hand, predictive surgical simulations, quantitative medical imaging, machine learning, and research ethics.

Related Links:

Teaching Profile

Courses Taught
2019-2021,2023-2025
BME3012 Clinically-Inspired Engineering Design
2019
BME6940 Supervised Teaching
2019
BME7979 Advanced Research
2019
BME6971 Research for Master’s Thesis
2018-2019
EGN4912 Engineering Directed Independent Research
2018
EGN6913 Engineering Graduate Research
2018
BME4931 Special Topics in Biomedical Engineering
2022-2024
BME6938 Special Topics in Biomedical Engineering
2022-2023
BME3219 Engineering Analysis of Musculoskeletal Biomechanics

Research Profile

Dr. Nichols’ research broadly focuses on musculoskeletal biomechanics. The guiding vision of her lab is to create predictive simulations that cross disciplinary boundaries and improve the functional ability and quality of life for individuals with musculoskeletal disorders. In other words, she is actively working to create a future in which advanced computer simulations enable real-time, patient-specific prognostics in a doctor’s office. Toward this goal, her lab is pursuing (i) basic science projects focused on understanding musculoskeletal structure and function, (ii) computationally intensive projects to rapidly create personalized models and analyze predictive patient-specific simulations, and (iii) clinical projects focused on improving orthopaedic surgery and rehabilitation. All these projects integrate orthopaedic biomechanics, musculoskeletal computer simulations, quantitative medical imaging, and machine learning to understand both the patient- and surgeon-specific factors that influence musculoskeletal health.

Open Researcher and Contributor ID (ORCID)

0000-0001-5167-9197

Publications

2024
Association of Muscle Quality and Pain in Adults With Symptomatic Knee Osteoarthritis, Independent of Muscle Strength: Findings From a Cross-Sectional Study.
Arthritis & rheumatology (Hoboken, N.J.). 76(7):1062-1070 [DOI] 10.1002/art.42834. [PMID] 38403452.
2024
Disease severity versus pain severity: Range of motion differences during single‐ and multiplanar tasks in women with carpometacarpal osteoarthritis
Journal of Orthopaedic Research. 42(8):1710-1718 [DOI] 10.1002/jor.25833. [PMID] 38483094.
2024
Explainable AI Elucidates Musculoskeletal Biomechanics: A Case Study Using Wrist Surgeries.
Annals of biomedical engineering. 52(3):498-509 [DOI] 10.1007/s10439-023-03394-9. [PMID] 37943340.
2024
Generational Leaps in Syndesmosis Imaging Research
Foot & Ankle International. [DOI] 10.1177/10711007241251829.
2024
Image Rotation Alters Apparent Fibula Length: An Evaluation of Talocrural Angle, Shenton Line, and Dime Sign
Foot & Ankle International. 45(3):236-242 [DOI] 10.1177/10711007231221991.
2024
Sensitivity Analysis of Upper Limb Musculoskeletal Models During Isometric and Isokinetic Tasks
Journal of Biomechanical Engineering. 146(2) [DOI] 10.1115/1.4064056. [PMID] 37978046.
2024
Syndesmosis Injury Contributes a Large Negative Effect on Clinical Outcomes: A Systematic Review.
Foot & ankle specialist. 17(3):284-294 [DOI] 10.1177/19386400211067865. [PMID] 35048741.
2023
A Musculoskeletal Model of the Hand and Wrist Capable of Simulating Functional Tasks
IEEE Transactions on Biomedical Engineering. 70(5):1424-1435 [DOI] 10.1109/tbme.2022.3217722.
2023
A Secondary Analysis: Comparison of Experimental Pain and Psychological Impact in Individuals with Carpometacarpal and Knee Osteoarthritis
Journal of Pain Research. Volume 16:4139-4149 [DOI] 10.2147/jpr.s421689.
2023
Biomechanical Sequelae of Syndesmosis Injury and Repair.
Foot and ankle clinics. 28(1):77-98 [DOI] 10.1016/j.fcl.2022.10.004. [PMID] 36822690.
2023
Inverse distance weighting to rapidly generate large simulation datasets.
Journal of biomechanics. 158 [DOI] 10.1016/j.jbiomech.2023.111764. [PMID] 37598434.
2023
Measuring fascicle lengths of extrinsic and intrinsic thumb muscles using extended field-of-view ultrasound.
Journal of biomechanics. 149 [DOI] 10.1016/j.jbiomech.2023.111512. [PMID] 36842405.
2023
Predictions of thumb, hand, and arm muscle parameters derived using force measurements of varying complexity and neural networks.
Journal of biomechanics. 161 [DOI] 10.1016/j.jbiomech.2023.111834. [PMID] 37865980.
2023
The Center-Center Image Closely Approximates Other Methods for Syndesmosis Reduction Clamp Placement
Foot & Ankle Specialist. [DOI] 10.1177/19386400231213741.
2022
Corrigendum to “Connecting the wrist to the hand: A simulation study exploring changes in thumb-tip endpoint force following wrist surgery” [J. Biomech. 58 (2017) 97-104].
Journal of biomechanics. 139 [DOI] 10.1016/j.jbiomech.2021.110859. [PMID] 34815070.
2022
Intraoperative Assessment of Reduction of the Ankle Syndesmosis
Current Reviews in Musculoskeletal Medicine. 15(5):344-352 [DOI] 10.1007/s12178-022-09769-0. [PMID] 35829893.
2022
Linear relationship between electromyography and shear wave elastography measurements persists in deep muscles of the upper extremity.
Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology. 63 [DOI] 10.1016/j.jelekin.2022.102645. [PMID] 35189570.
2021
Anthropometric scaling of musculoskeletal models of the hand captures age-dependent differences in lateral pinch force
Journal of Biomechanics. 123 [DOI] 10.1016/j.jbiomech.2021.110498. [PMID] 34062348.
2021
Classifying muscle parameters with artificial neural networks and simulated lateral pinch data
PLOS ONE. 16(9) [DOI] 10.1371/journal.pone.0255103. [PMID] 34473706.
2021
Simulating finger-tip force using two common contact models: Hunt-Crossley and elastic foundation
Journal of Biomechanics. 119 [DOI] 10.1016/j.jbiomech.2021.110334. [PMID] 33662749.
2021
The modified Shriners Hospitals for Children Greenville (mSHCG) multi-segment foot model provides clinically acceptable measurements of ankle and midfoot angles: A dual fluoroscopy study
Gait & Posture. 85:258-265 [DOI] 10.1016/j.gaitpost.2021.02.004. [PMID] 33626450.
2020
Compensatory Motion of the Subtalar Joint Following Tibiotalar Arthrodesis
Journal of Bone and Joint Surgery. 102(7):600-608 [DOI] 10.2106/jbjs.19.01132.
2020
Computed Tomographic Validation of the Center-Center Radiographic Technique for Syndesmosis Fixation Axis Alignment in Normal Ankles
Foot & Ankle International. 41(9):1143-1148 [DOI] 10.1177/1071100720936215.
2018
Simulated work-loops predict maximal human cycling power
Journal of Experimental Biology. [DOI] 10.1242/jeb.180109.
2017
Connecting the wrist to the hand: A simulation study exploring changes in thumb-tip endpoint force following wrist surgery.
Journal of biomechanics. 58:97-104 [DOI] 10.1016/j.jbiomech.2017.04.024. [PMID] 28552412.
2017
Decoupling the Wrist: A Cadaveric Experiment Examining Wrist Kinematics Following Midcarpal Fusion and Scaphoid Excision.
Journal of applied biomechanics. 33(1):12-23 [DOI] 10.1123/jab.2015-0324. [PMID] 27705062.
2017
Subject-Specific Axes of Rotation Based on Talar Morphology Do Not Improve Predictions of Tibiotalar and Subtalar Joint Kinematics.
Annals of biomedical engineering. 45(9):2109-2121 [DOI] 10.1007/s10439-017-1874-9. [PMID] 28639171.
2016
Predicting tibiotalar and subtalar joint angles from skin-marker data with dual-fluoroscopy as a reference standard
Gait & Posture. 49:136-143 [DOI] 10.1016/j.gaitpost.2016.06.031. [PMID] 27414041.
2016
Surgical Simulations Based on Limited Quantitative Data: Understanding How Musculoskeletal Models Can Be Used to Predict Moment Arms and Guide Experimental Design
PLOS ONE. 11(6) [DOI] 10.1371/journal.pone.0157346. [PMID] 27310013.
2015
Wrist salvage procedures alter moment arms of the primary wrist muscles.
Clinical biomechanics (Bristol, Avon). 30(5):424-30 [DOI] 10.1016/j.clinbiomech.2015.03.015. [PMID] 25843482.
2013
Orientations of wrist axes of rotation influence torque required to hold the hand against gravity: a simulation study of the nonimpaired and surgically salvaged wrist.
Journal of biomechanics. 46(1):192-6 [DOI] 10.1016/j.jbiomech.2012.10.035. [PMID] 23199898.
2005
Reduction in DNA synthesis during two-photon microscopy of intrinsic reduced nicotinamide adenine dinucleotide fluorescence.
Photochemistry and photobiology. 81(2):259-69 [PMID] 15647000.

Grants

Aug 2023 ACTIVE
Integrating Musculoskeletal and Data-Driven Modeling to Understand the Biomechanical Sequelae of Syndesmotic Repair
Role: Other
Funding: NATL INST OF HLTH NIAMS
Jul 2023 – Jun 2024
Nichols – VA IPA Agreement
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2022 ACTIVE
Innervation of the knee and TMJ
Role: Project Manager
Funding: NATL INST OF HLTH NIAMS
Sep 2022 – Jun 2023
Elucidating Principles of Sensorimotor Control using Deep Learning
Role: Other
Funding: NATL INST OF HLTH NIDA
Aug 2022 – Dec 2023
Integrating Biomechanics and Experimental Pain to Understand Compensatory Mechanisms in Symptomatic Carpometacarpal Osteoarthritis
Role: Other
Funding: NATL INST OF HLTH NIA
Jun 2022 ACTIVE
Team-Based Design for Clinical Translation
Role: Other
Funding: NATL INST OF HLTH NIBIB
Apr 2022 ACTIVE
Carpometacarpal Osteoarthritis: Understanding the Intersection of Muscle Mechanics, Joint Instability, and Pain
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2020 ACTIVE
A Transfer Learning Framework for Creating Subject-Specific Musculoskeletal Models of the Hand
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB
Jul 2020 – Jun 2021
Institutional Career Development Core
Role: Project Manager
Funding: NATL INST OF HLTH NCATS
Jul 2019 – Jun 2020
Together: Transforming and Translating Discovery to Improve Health
Role: Project Manager
Funding: NATL INST OF HLTH NCATS
Jul 2019 – Jun 2024
OoR Matching Support for CTSI
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS

Education

Postdoctoral Fellowship, Orthopaedic Biomechanics
2017 · University of Utah
M.A. Medical Humanities & Bioethics
2014 · Northwestern University
Ph.D. Biomedical Engineering
2014 · Northwestern University
M.S. Biomedical Engineering
2011 · Northwestern University
B.S. Mechanical Engineering
2008 · Tufts University

Contact Details

Phones:
Business:
(352) 294-8803
Emails:
Addresses:
Business Mailing:
PO BOX 116131
GAINESVILLE FL 326110001
Business Street:
1275 CENTER DR RM JG56
GAINESVILLE FL 32610